Women Leading a New Climate of Change. The world today is witnessing profound uncertainties due to the interwoven effect of various global challenges looming over the lives and future of millions of women and girls. At the same time, the trends of vigorous and substantive transformations are taking shape in the world. Sustainable development, green and inclusive growth and social welfare have become the main line of decision-making in many countries. Science, technology, and innovation continues to be a driver for the advancement of humanity. Digital transformation is creating fundamental shifts in governance, business and production, consumption, and social life alike. As an important and inseparable part of the world, women and young girls cannot stand aside from such movements of time. On the contrary, they must take the initiative to adapt and rise to opportunities to help realize these positive trends. Particularly, they must be involved in the making of conducive policies and institutions that help unlock and fully tap into every potential and strength of women, enabling their contributions to humanity’s progress. They must also be the decisive factor in eliminating gender-based prejudices and barriers.